Inclusion complexation with cyclodextrins

被引：0

作者：

Klein, CT ^{[1
]}

Viernstein, H ^{[1
]}

Wolschann, P ^{[1
]}

机构：

[1] Inst Theoret Chem & Mol Strukturbiol, A-1090 Vienna, Austria

来源：

MINERVA BIOTECNOLOGICA | 2000年 / 12卷 / 04期

关键词：

cyclodextrin; inclusion complexes; encapsulation; triflumizole; QSAR; bioavailability;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Inclusion of guest molecules into the hydrophobic cavity of various cyclodextrins changes the properties of these guest molecules, which can be used for a broad variety of applications. Prediction models obtained from QSAR studies lead to a better understanding of the inclusion mechanism. A special feature of such complexation is the enthalpy-entropy compensation and pronounced solubility enhancements, which are used for better bioavailabilty of drugs and, in the case of biocides for a reduction of the biologically active compounds by equal activity.

引用

页码：287 / 292

页数：6

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