Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition

被引：106
|
作者：
Zheng, Jukuan [1 ]
Callahan, Laura A. Smith [1 ]
Hao, Jinkun [2 ]
Guo, Kai [1 ]
Wesdemiotis, Chrys [1 ,3 ]
Weiss, R. A. [2 ]
Becker, Matthew L. [1 ,4 ]
机构：
[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA
[2] Univ Akron, Dept Polymer Engn, Akron, OH 44325 USA
[3] Univ Akron, Dept Chem, Akron, OH 44325 USA
[4] Austen Bioinnovat Inst Akron, Ctr Biomat Med, Akron, OH 44308 USA
来源：
ACS MACRO LETTERS | 2012年 / 1卷 / 08期
基金：
美国国家科学基金会;
关键词：
CLICK CHEMISTRY; PEPTIDE; DESIGN; POLYMER;
D O I：
10.1021/mz3003775
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The synthesis of a 4-dibenzocyclooctyriol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain promoted, metal free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross linking mechanisms.
引用
收藏
页码：1071 / 1073
页数：3
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