Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition

被引：106
|
作者：
Zheng, Jukuan [1 ]
Callahan, Laura A. Smith [1 ]
Hao, Jinkun [2 ]
Guo, Kai [1 ]
Wesdemiotis, Chrys [1 ,3 ]
Weiss, R. A. [2 ]
Becker, Matthew L. [1 ,4 ]
机构：
[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA
[2] Univ Akron, Dept Polymer Engn, Akron, OH 44325 USA
[3] Univ Akron, Dept Chem, Akron, OH 44325 USA
[4] Austen Bioinnovat Inst Akron, Ctr Biomat Med, Akron, OH 44308 USA
来源：
ACS MACRO LETTERS | 2012年 / 1卷 / 08期
基金：
美国国家科学基金会;
关键词：
CLICK CHEMISTRY; PEPTIDE; DESIGN; POLYMER;
D O I：
10.1021/mz3003775
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The synthesis of a 4-dibenzocyclooctyriol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain promoted, metal free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross linking mechanisms.
引用
收藏
页码：1071 / 1073
页数：3
相关论文
共 29 条
  • [1] Copper-Free Click Biofunctionalization of Silicon Nitride Surfaces via Strain-Promoted Alkyne-Azide Cycloaddition Reactions
    Manova, Radostina K.
    Pujari, Sidharam P.
    Weijers, Carel A. G. M.
    Zuilhof, Han
    van Beek, Tens A.
    LANGMUIR, 2012, 28 (23) : 8651 - 8663
  • [2] Strain-Promoted Cycloadditions for Development of Copper-Free Click Reactions
    Pigge, F. Christopher
    CURRENT ORGANIC CHEMISTRY, 2016, 20 (18) : 1902 - 1922
  • [3] An injectable PEG-based hydrogel synthesized by strain-promoted alkyne-azide cycloaddition for use as an embolic agent
    Su, Xin
    Bu, Linlin
    Dong, Hui
    Fu, Shuangli
    Zhuo, Renxi
    Zhong, Zhenlin
    RSC ADVANCES, 2016, 6 (04): : 2904 - 2909
  • [4] Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Cross-Linked by Copper-Free, Strain-Promoted Click Chemistry
    Xu, Jianwen
    Filion, Tera M.
    Prifti, Fioleda
    Song, Jie
    CHEMISTRY-AN ASIAN JOURNAL, 2011, 6 (10) : 2730 - 2737
  • [5] Reproducible Dendronized PEG Hydrogels via SPAAC Cross-Linking
    Hodgson, Sabrina M.
    McNelles, Stuart A.
    Abdullahu, Leonora
    Marozas, Ian A.
    Anseth, Kristi S.
    Adronov, Alex
    BIOMACROMOLECULES, 2017, 18 (12) : 4054 - 4059
  • [6] Strain-Promoted Copper-Free "Click" Chemistry for 18F Radiolabeling of Bombesin
    Campbell-Verduyn, Lachlan S.
    Mirfeizi, Leila
    Schoonen, Anne K.
    Dierckx, Rudi A.
    Elsinga, Philip H.
    Feringa, Ben L.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (47) : 11117 - 11120
  • [7] Fused Bicyclic Caspase-1 Inhibitors Assembled by Copper-Free Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC)
    Qian, Linghui
    Zhang, Chong-Jing
    Wu, Ji'en
    Yao, Shao Q.
    CHEMISTRY-A EUROPEAN JOURNAL, 2017, 23 (02) : 360 - 369
  • [8] Properties of Poly(ethylene glycol) Hydrogels Cross-Linked via Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC)
    Hodgson, Sabrina M.
    Bakaic, Emilia
    Stewart, S. Alison
    Hoare, Todd
    Adronov, Alex
    BIOMACROMOLECULES, 2016, 17 (03) : 1093 - 1100
  • [9] Strain-promoted azide-alkyne cycloaddition for protein-protein coupling in the formation of a bis-hemoglobin as a copper-free oxygen carrier
    Singh, Serena
    Dubinsky-Davidchik, Ina S.
    Kluger, Ronald
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (42) : 10011 - 10017
  • [10] Site-specific labeling of transcription factors using noncanonical amino acids and strain-promoted [2+3] cycloaddition via copper-free Click Chemistry
    Kim, Younghoon
    Kim, Sung Hoon
    Katzenellenbogen, John A.
    Schroeder, Charles M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
123