Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives

被引：3

作者：

Jubie, Selvaraj ^{[1
,2
]}

Gayathri, Rajamanickam ^{[1
]}

Kalirajan, Rajagopal ^{[1
]}

机构：

[1] JSS Univ, Dept Pharmaceut Chem, JSS Coll Pharm, Mysore 570015, Karnataka, India

[2] JSS Coll Pharm, Dept Pharmaceut Chem, Rocklands 643001, Ooty, India

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

关键词：

D O I：

10.1100/2012/718023

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using H-1 NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. For the purpose, different screening methods such as open field exploratory behavior test, rota rod test, grip strength test, beam walk test, and photo actometer test were performed. Ethidium bromide induction showed muscle weakness; muscle discoordination; loss of locomotor activity, and so forth, the synthesized drugs reversed all the above-mentioned neuromuscular disorders caused by ethidium bromide administration.

引用

页数：8

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