Intensity-modulated radiotherapy for head and neck cancer. Dose constraint for salivary gland and mandible

被引：12
|
作者：
Pointreau, Y. [1 ]
Lizee, T. [1 ,2 ]
Bensadoun, R. -J. [3 ]
Boisselier, P. [4 ]
Racadot, S. [5 ]
Thariat, J. [6 ]
Graff, P. [7 ]
机构：
[1] Ctr Jean Bernard, Inst Interreg Cancerol, Clin Victor Hugo, 9 Rue Beauverger, F-72000 Le Mans, France
[2] Inst Cancerol Ouest Paul Papin, 15 Rue Andre Boquel, F-49055 Angers 02, France
[3] Ctr Haute Energie, Inst Nicois Cancerol & Imagerie, 10 Blvd Pasteur, F-06000 Nice, France
[4] Inst Canc Montpellier, Dept Radiotherapie, 208 Ave Apothicaires,Parc Euromed, F-34298 Montpellier 5, France
[5] Ctr Leon Berard, Dept Radiotherapie, 28 Rue Laennec, F-69008 Lyon, France
[6] Ctr Antoine Lacassagne, Dept Radiotherapie, 33 Ave Valombrose, F-06189 Nice, France
[7] Inst Univ Canc Toulouse Oncopole, Serv Radiotherapie & Curietherapie, 1 Ave Irene Joliot Curie, F-31100 Toulouse, France
来源：
CANCER RADIOTHERAPIE | 2016年 / 20卷 / 6-7期
关键词：
Head and neck cancer; Intensity-modulated radiotherapy; Organ at risk; Mandible; Salivary gland; PATIENT-RATED XEROSTOMIA; PAROTID-GLAND; NASOPHARYNGEAL CARCINOMA; RADIATION-THERAPY; RETROSPECTIVE ANALYSIS; STICKY SALIVA; OSTEORADIONECROSIS; IRRADIATION; IMRT; MODELS;
D O I：
10.1016/j.canrad.2016.07.066
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intensity-modulated radiation therapy (IMRT) is the gold standard for head and neck irradiation. It allows better protection to the organs at risk such as salivary glands and mandible, and can reduce the frequency of xerostomia, trismus and osteoradionecrosis. At the time of treatment planning, the mean dose to a single parotid gland should be kept below 26 Gy, the mean dose to a single submandibular gland below 39 Gy, the mean dose to the mandible below 60 to 65 Gy and the D-2% to a single temporomandibular joint below 65 Gy. These dose constraints could be further improved with data extracted from cohorts of patients receiving IMRT exclusively. The dose administered to the target volumes should not be lessened to spare the salivary glands or mandible. (C) 2016 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：445 / 451
页数：7
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