New approach for characterization of post-translationally modified peptides using ion trap MS with combined ETD-CID fragmentation

被引：0

作者：

Hartmer, R ^{[1
]}

Lubeck, M ^{[1
]}

机构：

[1] Bruker Dalton Inc, Billerica, MA 01821 USA

来源：

LC GC NORTH AMERICA | 2005年

关键词：

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel tandem mass spectrometry instrument (PTM Discovery System (TM)) offers the application of two different MS fragmentation techniques (i.e., collisionally-induced dissociation, CID, and electrontransfer dissociation, ETD) showing highly complementary fragmentation results with a short duty cycle, allowing fast peptide identification and characterization with on-line separation techniques. The information obtained from both techniques is suited ideally for the characterization of posttranslational modifications (PTM), such as phosphorylation.

引用

页码：14 / 14

页数：1

共 24 条

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