New approach for characterization of post-translationally modified peptides using ion trap MS with combined ETD-CID fragmentation

被引：0
|
作者：
Hartmer, R [1 ]
Lubeck, M [1 ]
机构：
[1] Bruker Dalton Inc, Billerica, MA 01821 USA
来源：
LC GC NORTH AMERICA | 2005年
关键词：
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A novel tandem mass spectrometry instrument (PTM Discovery System (TM)) offers the application of two different MS fragmentation techniques (i.e., collisionally-induced dissociation, CID, and electrontransfer dissociation, ETD) showing highly complementary fragmentation results with a short duty cycle, allowing fast peptide identification and characterization with on-line separation techniques. The information obtained from both techniques is suited ideally for the characterization of posttranslational modifications (PTM), such as phosphorylation.
引用
收藏
页码：14 / 14
页数：1
相关论文
共 24 条
  • [1] New approach for characterization of post translational modified peptides using ion trap MS with combined ETD/CID fragmentation
    Hartmer, R
    Lubeck, M
    [J]. LC GC EUROPE, 2005, : 11 - 13
  • [2] Improved characterization of glycopeptides using CID and ETD ion trap MS/MS
    Wuhrer, M.
    Lubeck, M.
    Hartmer, R.
    Brekenfeld, A.
    Koeleman, C. A. M.
    Deelder, A. M.
    Stacey, C.
    Baessmann, C.
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (10) : S234 - S234
  • [3] Detecting diagnostic features in MS/MS spectra of post-translationally modified peptides
    Daniel J. Geiszler
    Daniel A. Polasky
    Fengchao Yu
    Alexey I. Nesvizhskii
    [J]. Nature Communications, 14
  • [4] Detecting diagnostic features in MS/MS spectra of post-translationally modified peptides
    Geiszler, Daniel J.
    Polasky, Daniel A.
    Yu, Fengchao
    Nesvizhskii, Alexey I.
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [5] Post-translationally modified peptides - New targets in autoimmune disease?
    Purcell, A. W.
    Lau, K.
    Drummond, B.
    Williamson, N. A.
    Roberts, L. J.
    Mannering, S. I.
    Harrision, L. C.
    [J]. JOURNAL OF PEPTIDE SCIENCE, 2006, 12 : 95 - 95
  • [6] Digging deeper into the immunopeptidome: characterization of post-translationally modified peptides presented by MHC I
    Kiran K. Mangalaparthi
    Anil K. Madugundu
    Zachary C. Ryan
    Kishore Garapati
    Jane A. Peterson
    Gourav Dey
    Amol Prakash
    Akhilesh Pandey
    [J]. Journal of Proteins and Proteomics, 2021, 12 (3) : 151 - 160
  • [7] Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae
    Huo, Liujie
    Zhao, Xiling
    Acedo, Jeella Z.
    Estrada, Paola
    Nair, Satish K.
    van der Donk, Wilfred A.
    [J]. CHEMBIOCHEM, 2020, 21 (1-2) : 190 - 199
  • [8] High field asymmetric waveform ion mobility spectrometry (FAIMS) and electron transfer dissociation (ETD) mass spectrometry for the analysis of post-translationally modified peptides
    Creese, Anrew J.
    Smart, Jade
    Zampronio, Cleidiane G.
    Cooper, Helen J.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [9] Detection of post-translationally modified peptide biomarkers using ion mobility spectrometry platforms
    Shvartsburg, Alexandre A.
    Ibrahim, Yehia M.
    Smith, Richard D.
    Belov, Mikhail E.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [10] Genome Mining for Discovery of New Post-Translationally Modified Peptides in Cyanobacteria from LEGE Culture Collection
    Branco, Raquel Castelo
    Vasconcelos, Vitor
    Fewer, David
    Leao, Pedro
    [J]. MARINE DRUGS, 2020, 18 (01)
123