(Z)-Selective Hydrosilylation of Terminal Alkynes with HSiMe(OSiMe3)2 Catalyzed by a Ruthenium Complex Containing an N-Heterocyclic Carbene

被引：35

作者：

Mutoh, Yuichiro ^{[1
]}

Mohara, Yusei ^{[1
]}

Saito, Shinichi ^{[1
]}

机构：

[1] Tokyo Univ Sci, Dept Chem, Fac Sci, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 19期

关键词：

C-H SILYLATION; OLEFIN-METATHESIS; DEHYDROGENATIVE SILYLATION; HYDRIDE; REGIO; ISOMERIZATION; CYCLOISOMERIZATION; (E)-ALKENYLSILANES; SILYLVINYLATION; 1-ALKYNES;

D O I：

10.1021/acs.orglett.7b02477

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-heterocyclic-carbene-ligated ruthenium complex [RuHCl(CO)(H(2)IMes)(PCy3)] exhibits high catalytic activity for the (Z)-selective hydrosilylation of various terminal alkynes with 1,1,1,3,5,5,5-heptamethyltrisiloxane (HSiMe-(OSiMe3)(2)). The stereoretentive derivatization of the (Z)-alkenylsiloxanes allows the synthesis of biologically active compounds, e.g. potent antitumor agents and inhibitors for induced-NO synthase.

引用

页码：5204 / 5207

页数：4

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