(Z)-Selective Hydrosilylation of Terminal Alkynes with HSiMe(OSiMe3)2 Catalyzed by a Ruthenium Complex Containing an N-Heterocyclic Carbene

被引：35
|
作者：
Mutoh, Yuichiro [1 ]
Mohara, Yusei [1 ]
Saito, Shinichi [1 ]
机构：
[1] Tokyo Univ Sci, Dept Chem, Fac Sci, Shinjuku Ku, 1-3 Kagurazaka, Tokyo 1628601, Japan
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 19期
关键词：
C-H SILYLATION; OLEFIN-METATHESIS; DEHYDROGENATIVE SILYLATION; HYDRIDE; REGIO; ISOMERIZATION; CYCLOISOMERIZATION; (E)-ALKENYLSILANES; SILYLVINYLATION; 1-ALKYNES;
D O I：
10.1021/acs.orglett.7b02477
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The N-heterocyclic-carbene-ligated ruthenium complex [RuHCl(CO)(H(2)IMes)(PCy3)] exhibits high catalytic activity for the (Z)-selective hydrosilylation of various terminal alkynes with 1,1,1,3,5,5,5-heptamethyltrisiloxane (HSiMe-(OSiMe3)(2)). The stereoretentive derivatization of the (Z)-alkenylsiloxanes allows the synthesis of biologically active compounds, e.g. potent antitumor agents and inhibitors for induced-NO synthase.
引用
收藏
页码：5204 / 5207
页数：4
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