Pd-Catalyzed Dearboxylative Heck Coupling with Dioxygen as the Terminal Oxidant

被引：94
|
作者：
Fu, Zhengjiang [1 ]
Huang, Shijun [1 ]
Su, Weiping [1 ]
Hong, Maochun [1 ]
机构：
[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 21期
关键词：
ARENE CARBOXYLIC-ACIDS; MOLECULAR-OXYGEN; BENZOIC-ACIDS; VERSATILE CATALYST; DECARBOXYLATIVE OLEFINATION; OXIDATIVE AMINATION; DIRECT ARYLATION; ARYL BROMIDES; H ACTIVATION; ALKENES;
D O I：
10.1021/ol102158n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pd-catalyzed decarboxylative Heck coupling of aromatic carboxylic acids with various olefins is developed using O-2 as the terminal oxidant. Enhancement of O-2 pressure leads to improving reaction turnover in this transformation and allows significantly reducing catalyst loading for efficient conversion of electron-rich benzoic acids. A Pd catalyst supported by a carbene ligand enables using electron-deficient benzoic acids as coupling partners.
引用
收藏
页码：4992 / 4995
页数：4
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