Pd-Catalyzed Enantioselective Double Heck Reaction

被引：36
|
作者：
Ju, Baihang [1 ]
Chen, Shigui [1 ]
Kong, Wangqing [1 ]
机构：
[1] Wuhan Univ, IAS, CPS, Wuhan 430072, Hubei, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 23期
基金：
中国国家自然科学基金;
关键词：
ANION PHASE-TRANSFER; MATSUDA ARYLATIONS; ARYL-ALKENYLATION; CASCADE REACTIONS; ACYCLIC OLEFINS; MORPHINE; EFFICIENT; ALKENES; DIFUNCTIONALIZATION; DIHYDROBENZOFURAN;
D O I：
10.1021/acs.orglett.9b03517
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric Pd-catalyzed intramolecular followed by an intermolecular double Heck reaction of arenediazonium salts with simple alkenes is disclosed. This reaction features mild reaction conditions, simple operation, and excellent functional group tolerance and provides a rapid access to functionalized dihydrobenzofurans bearing all carbon quaternary centers in good regioselectivity (>95/5) and enantioselectivity (90-99% ee).
引用
收藏
页码：9343 / 9347
页数：5
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