Thyrotropin-releasing hormone in regulation of focal epilepsy

Peculiarities of the formation of primary and mirror (contralateral) epileptic focuses were studied using the model of focal cobalt-induced epilepsy of rabbits. The time intervals for the formation of primary and secondary epileptic focuses in the frontal cerebral cortex of rabbits and generalization of seizure activity were investicated. Fractal analysis was used for evaluation of the electric activity of the cerebral cortex. The anti-seizure activity of the thyrotropin-releasing hormone (TRH) was examined after its intranasal administration in the concentrations of 10(-12) and 10(-9) mol/l. The inhibitory effect of TRH at the concentration studied on the current cobalt-induced epileptic activity of the brain was demonstrated. However, a significant increase in epileptic activity was observed after the intravenous injection of rabbits by TRH in the doses of 25, 50, and 100 mu g/kg.