Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography

被引：14

作者：

Ibrahim, Wan Aini Wan ^{[1
,2
]}

Abd Wahib, Siti Munirah ^{[1
]}

Hermawan, Dadan ^{[2
]}

Sanagi, Mohd Marsin ^{[1
,2
]}

Aboul-Enein, Hassan Y. ^{[3
]}

机构：

[1] Univ Teknol Malaysia, Dept Chem, Fac Sci, Separat Sci & Technol Grp SepSTec, Utm Johor Bahru 81310, Johor, Malaysia

[2] Univ Teknol Malaysia, Ibnu Sina Inst Fundamental Sci Studies, Utm Johor Bahru 81310, Johor, Malaysia

[3] Natl Res Ctr, Dept Pharmaceut & Med Chem, Cairo, Egypt

来源：

CHIRALITY | 2012年 / 24卷 / 03期

关键词：

enantioseparation; vinpocetine; cyclodextrins; cyclodextrin-modified micellar electrokinetic chromatography; capillary electrophoresis; CAPILLARY-ELECTROPHORESIS; ENANTIOSEPARATION;

D O I：

10.1002/chir.21990

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-beta-CD (HP-beta-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-beta-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25 degrees C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.043.87. Chirality, 2012. (C) 2012 Wiley Periodicals, Inc.

引用

页码：252 / 254

页数：3

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