Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography

被引：14
|
作者：
Ibrahim, Wan Aini Wan [1 ,2 ]
Abd Wahib, Siti Munirah [1 ]
Hermawan, Dadan [2 ]
Sanagi, Mohd Marsin [1 ,2 ]
Aboul-Enein, Hassan Y. [3 ]
机构：
[1] Univ Teknol Malaysia, Dept Chem, Fac Sci, Separat Sci & Technol Grp SepSTec, Utm Johor Bahru 81310, Johor, Malaysia
[2] Univ Teknol Malaysia, Ibnu Sina Inst Fundamental Sci Studies, Utm Johor Bahru 81310, Johor, Malaysia
[3] Natl Res Ctr, Dept Pharmaceut & Med Chem, Cairo, Egypt
来源：
CHIRALITY | 2012年 / 24卷 / 03期
关键词：
enantioseparation; vinpocetine; cyclodextrins; cyclodextrin-modified micellar electrokinetic chromatography; capillary electrophoresis; CAPILLARY-ELECTROPHORESIS; ENANTIOSEPARATION;
D O I：
10.1002/chir.21990
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-beta-CD (HP-beta-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-beta-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25 degrees C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.043.87. Chirality, 2012. (C) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：252 / 254
页数：3
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