Genome-wide functions of PML-RARα in acute promyelocytic leukaemia

被引：49
|
作者：
Saeed, S. [1 ]
Logie, C. [1 ]
Stunnenberg, H. G. [1 ]
Martens, J. H. A. [1 ]
机构：
[1] Radboud Univ Nijmegen, Fac Sci, Nijmegen Ctr Mol Life Sci, Dept Mol Biol, NL-6500 HB Nijmegen, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 04期
关键词：
PML-RAR alpha; RXR; PU.I (SPII); epigenome; TRANSCRIPTION FACTOR; HISTONE DEACETYLASE; FUSION PROTEINS; RECEPTOR; PU.1; RXR; TRANSLOCATION; RECRUITMENT; DEGRADATION; T(15-17);
D O I：
10.1038/sj.bjc.6606095
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PML-RAR (retinoic acid receptor) a is the hallmark protein of acute promyelocytic leukaemia, a highly malignant subtype of acute myeloid leukaemia that accounts for approximately 10% of all AML cases. Recently, several studies have been set out to obtain a comprehensive genome-wide view of the molecular actions of this chimeric protein. In this review, we highlight the new insights that arose from these studies, in particular focussing on newly identified PML-RAR alpha target genes, its interplay with RXR and deregulation of epigenetic modifications. British Journal of Cancer (2011) 104, 554-558. doi:10.1038/sj.bjc.6606095 www.bjcancer.com Published online 18 January 2011 (C) 2011 Cancer Research UK
引用
收藏
页码：554 / 558
页数：5
相关论文
共 50 条
  • [21] PML Mutation in PML-Rarα Alters PML Nuclear Body Organization and Induces ATRA Resistance in Acute Promyelocytic Leukemia
    Zhu, Hong-Hu
    Wu, Congying
    Sun, Yujie
    Hu, Jiong
    BLOOD, 2018, 132
  • [22] Identification of two atypical PML-RARα transcripts in two patients with acute promyelocytic leukemia
    Barragán, E
    Bolufer, P
    Martín, G
    Cervera, J
    Moreno, I
    Capote, FJ
    Rosique, P
    Sanz, MA
    LEUKEMIA RESEARCH, 2002, 26 (05) : 439 - 442
  • [23] Quantitative RT-PCR of PML-RAR alpha transcripts in acute promyelocytic leukemia
    Iland, H
    Springall, F
    Zeng, T
    Bradfield, K
    MOLECULAR BIOLOGY OF HEMATOPOIESIS 5, 1996, : 269 - 276
  • [24] PML-RARα fusion gene transcripts and biological features in acute promyelocytic leukemia patients
    Melo, RAM
    De Vasconcellos, JF
    Melo, FCBC
    Machado, CGF
    Lacerda, TMS
    Souto, FR
    CLINICAL AND LABORATORY HAEMATOLOGY, 2006, 28 (02): : 126 - 129
  • [25] Neutrophil elastase cleaves PML-RARα and is important for the development of acute promyelocytic leukemia in mice
    Lane, AA
    Ley, TJ
    CELL, 2003, 115 (03) : 305 - 318
  • [26] PML-RARα and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic Leukemia
    Subramanyam, Deepa
    Belair, Cassandra D.
    Barry-Holson, Keegan Q.
    Lin, Haijiang
    Kogan, Scott C.
    Passegue, Emmanuelle
    Blelloch, Robert
    CANCER RESEARCH, 2010, 70 (21) : 8792 - 8801
  • [27] The aberrant fusion proteins PML-RARα and PLZF-RARα contribute to the overexpression of cyclin Al in acute promyelocytic leukemia
    Müller, C
    Yang, R
    Park, DJ
    Serve, H
    Berdel, WE
    Koeffler, HP
    BLOOD, 2000, 96 (12) : 3894 - 3899
  • [28] Sublethal irradiation potentiates the development of PML-RARα-driven acute promyelocytic leukemia in mice.
    Walter, MJ
    Park, JS
    Ley, TJ
    BLOOD, 2002, 100 (11) : 307A - 307A
  • [29] C-fms expression correlates with monocytic differentiation in PML-RARα+ acute promyelocytic leukemia
    Riccioni, R
    Saulle, E
    Militi, S
    Sposi, NM
    Gualtiero, M
    Mauro, N
    Mancini, M
    Diverio, D
    Lo Coco, F
    Peschle, C
    Testa, U
    LEUKEMIA, 2003, 17 (01) : 98 - 113
  • [30] C-fms expression correlates with monocytic differentiation in PML-RARα+ acute promyelocytic leukemia
    R Riccioni
    E Saulle
    S Militi
    N M Sposi
    M Gualtiero
    N Mauro
    M Mancini
    D Diverio
    F Lo Coco
    C Peschle
    U Testa
    Leukemia, 2003, 17 : 98 - 113
12345