Rapid adoption and production deployments of connected devices, coupled with AI-driven methods of advanced analytics, have led to an explosion in demand for non-traditional, more scalable computing and data management platforms. This increasing demand is being seen in the public cloud as well as in cloud-connected IoT edge devices. AI is at the heart of many the newest, most advanced analytics and IoT applications, ranging from robotics and autonomous vehicles, to cloud-connected products such as Amazon Alexa, to smart factories and consumer-facing services in the financial and healthcare sectors. This talk presents examples of such use-cases within Amazon, as well examples of how Amazon customers increasingly rely on AI coupled with IoT hardware and software stacks, and use cloud-based EDA to innovate faster, and at cloud scales.