New nucleoside analogs, synthesis, and biological properties

被引：7

作者：

Wanner, MJ ^{[1
]}

Deghati, PYF ^{[1
]}

Rodenko, B ^{[1
]}

Koomen, GJ ^{[1
]}

机构：

[1] Univ Amsterdam, IMC, Bioorgan Chem Lab, NL-1018 WS Amsterdam, Netherlands

来源：

PURE AND APPLIED CHEMISTRY | 2000年 / 72卷 / 09期

关键词：

D O I：

10.1351/pac200072091705

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In view of the importance of nucleoside analogs as enzyme inhibitors and adenosine receptor (ant)agonists, new adenosine analogs were prepared and their activities studied on adenosine deaminase in vitro and on A(1), A(2A), and A(3) receptors. Particularly useful for the synthesis of new analogs were the applications of the Pd-catalyzed Buchwald reaction and a radical nitration reaction of purine- and 1-deazapurine nucleosides.

引用

页码：1705 / 1708

页数：4

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