Lack of association between polymorphisms within the macrophage migration inhibitory factor (MIF) and the susceptibility to Rheumatoid Arthritis (RA)

被引：0
|
作者：
de la Fontaine, L [1 ]
Schwarz, MJ [1 ]
Plischke, H [1 ]
Zill, P [1 ]
Gruber, R [1 ]
机构：
[1] Univ Klinikum Munchen, Rheumaeinheit Med Poliklin, D-80336 Munich, Germany
来源：
IMMUNOLOGY 2004: AUTOIMMUNITY, GENETIC AND DEGENERATIVE DISORDERS, MALIGNANCIES, AND TRANSPLANTATION | 2004年
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D O I：
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中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The MIF gene as an interesting candidate for the aetiology and severity of Rheumatoid Arthritis was analysed for the G173C polymorphism and the CATT repeats in 119 patients. Our data showed no significant association of the 5-CATT repeat with RA, neither with susceptibility nor with severity, the same was true for the MIF G173C polymorphism. Interestingly we could find a significant correlation between homozygosity for the 7-CATT allele with a strong increase of the disease activity parameters RF and CRP.
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页码：53 / 57
页数：5
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