ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime

被引：1
|
作者：
Quatrini, Linda [1 ]
Moretta, Lorenzo [1 ]
Mingari, Maria Cristina [2 ,3 ,4 ]
机构：
[1] IRCSS Bambino Gesu Childrens Hosp, Dept Immunol, Rome 00146, Italy
[2] Univ Genoa, Dept Expt Med DIMES, Genoa 16132, Italy
[3] Univ Genoa, Ctr Excellence Biomed Res CEBR, Genoa 16132, Italy
[4] IRCCS Osped Policlinico San Martino, UOC Immunol Unit, Genoa 16132, Italy
来源：
TRENDS IN IMMUNOLOGY | 2020年 / 41卷 / 05期
基金：
欧盟地平线“2020”;
关键词：
D O I：
10.1016/j.it.2020.03.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal immunity by inducing ILC3s to produce protective IL-22.
引用
收藏
页码：364 / 366
页数：4
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