Targeting Tumor Hypoxia With Hypoxia-Activated Prodrugs

被引：41
|
作者：
Yeh, Jen Jen [1 ]
Kim, William Y. [1 ]
机构：
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2015年 / 33卷 / 13期
关键词：
PHASE-III TRIAL; PANCREATIC-CANCER; SOLID TUMORS; ANTITUMOR-ACTIVITY; CELL CARCINOMA; ONCOLOGY-GROUP; THERAPY; DOXORUBICIN; BREAST; ADENOCARCINOMA;
D O I：
10.1200/JCO.2014.60.0759
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
[No abstract available]
引用
收藏
页码：1505 / 1508
页数：4
相关论文
共 50 条
  • [41] Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy
    Gerard, Yvain
    Voissiere, Aurelien
    Peyrode, Caroline
    Galmier, Marie-Josephe
    Maubert, Elise
    Ghedira, Donia
    Tarrit, Sebastien
    Gaumet, Vincent
    Canitrot, Damien
    Miot-Noirault, Elisabeth
    Chezal, Jean-Michel
    Weber, Valerie
    BIOORGANIC CHEMISTRY, 2020, 98
  • [42] Precise gliomas therapy: Hypoxia-activated prodrugs sensitized by nano-photosensitizers
    Zhang, Han
    Shi, Chao
    Han, Fuping
    Li, Mengqi
    Ma, He
    Sui, Rui
    Long, Saran
    Sun, Wen
    Du, Jianjun
    Fan, Jiangli
    Piao, Haozhe
    Peng, Xiaojun
    BIOMATERIALS, 2022, 289
  • [43] A hypoxia-activated antibacterial prodrug
    Yeoh, Yuan Qi
    Horsley, John R.
    Polyak, Steven W.
    Abell, Andrew D.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (11)
  • [44] Hypoxia Imaging As a Guide for Hypoxia-Modulated and Hypoxia-Activated Therapy
    Brender, Jeffrey R.
    Saida, Yu
    Devasahayam, Nallathamby
    Krishna, Murali C.
    Kishimoto, Shun
    ANTIOXIDANTS & REDOX SIGNALING, 2022, 36 (1-3) : 144 - 159
  • [45] Hypoxia-activated anticancer drugs
    Denny, WA
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2005, 15 (06) : 635 - 646
  • [46] A hypoxia-activated NO donor for the treatment of myocardial hypoxia injury
    Zhou, Wen
    Yang, Wanxiang
    Fan, Keyu
    Hua, Wuyang
    Gou, Shaohua
    CHEMICAL SCIENCE, 2022, 13 (12) : 3549 - 3555
  • [47] Hypoxia-Activated Prodrugs with Dual COX-2/CA Inhibitory Effects on Attenuating Cardiac Inflammation under Hypoxia
    Zhou, Wen
    Wang, Chunping
    Liu, Zhikun
    Gou, Shaohua
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (19) : 13436 - 13451
  • [48] Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cells
    Li, Quhuan
    Lin, Qun
    Yun, Zhong
    CANCER BIOLOGY & THERAPY, 2016, 17 (12) : 1266 - 1273
  • [49] Selective Thrombosis of Tumor for Enhanced Hypoxia-Activated Prodrug Therapy
    Ma, Zhaoyu
    Zhang, Yifan
    Dai, Xinxin
    Zhang, Weiyun
    Foda, Mohamed F.
    Zhang, Jin
    Zhao, Yanli
    Han, Heyou
    ADVANCED MATERIALS, 2021, 33 (41)
  • [50] Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia
    Cheng, Weiyan
    Li, Shasha
    Wen, Xueqian
    Han, Siyuan
    Wang, Suhua
    Wei, Han
    Song, Zhizhen
    Wang, Yueqin
    Tian, Xin
    Zhang, Xiaojian
    CHEMICAL COMMUNICATIONS, 2021, 57 (95) : 12852 - 12855
12345