Galectins and Ovarian Cancer

被引:19
|
作者
Shimada, Chisa [1 ,2 ]
Xu, Rui [1 ,2 ]
Al-Alem, Linah [1 ,2 ]
Stasenko, Marina [3 ]
Spriggs, David R. [1 ,4 ]
Rueda, Bo R. [1 ,2 ,5 ]
机构
[1] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Vincent Ctr Reprod Biol, Boston, MA 02114 USA
[2] Harvard Med Sch, Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA
[3] Mem Sloan Kettering Canc Ctr, Gynecol Serv, 1275 York Ave, New York, NY 10065 USA
[4] Massachusetts Gen Hosp, Dept Hematol Med Oncol, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol, Boston, MA 02114 USA
关键词
ovarian cancer; galectins; invasion; metastasis; chemoresistance; immune suppression; GALACTOSIDE-BINDING LECTIN; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR PROGRESSION; PROSTATE-CANCER; ELECTRIC ORGAN; CELL-MIGRATION; T-CELLS; APOPTOSIS; EXPRESSION; CARCINOMA;
D O I
10.3390/cancers12061421
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ovarian cancer is known for its aggressive pathological features, including the capacity to undergo epithelial to mesenchymal transition, promoting angiogenesis, metastatic potential, chemoresistance, inhibiting apoptosis, immunosuppression and promoting stem-like features. Galectins, a family of glycan-binding proteins defined by a conserved carbohydrate recognition domain, can modulate many of these processes, enabling them to contribute to the pathology of ovarian cancer. Our goal herein was to review specific galectin members identified in the context of ovarian cancer, with emphasis on their association with clinical and pathological features, implied functions, diagnostic or prognostic potential and strategies being developed to disrupt their negative actions.
引用
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页数:28
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