Galectins and Ovarian Cancer

被引:19
|
作者
Shimada, Chisa [1 ,2 ]
Xu, Rui [1 ,2 ]
Al-Alem, Linah [1 ,2 ]
Stasenko, Marina [3 ]
Spriggs, David R. [1 ,4 ]
Rueda, Bo R. [1 ,2 ,5 ]
机构
[1] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Vincent Ctr Reprod Biol, Boston, MA 02114 USA
[2] Harvard Med Sch, Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA
[3] Mem Sloan Kettering Canc Ctr, Gynecol Serv, 1275 York Ave, New York, NY 10065 USA
[4] Massachusetts Gen Hosp, Dept Hematol Med Oncol, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol, Boston, MA 02114 USA
关键词
ovarian cancer; galectins; invasion; metastasis; chemoresistance; immune suppression; GALACTOSIDE-BINDING LECTIN; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR PROGRESSION; PROSTATE-CANCER; ELECTRIC ORGAN; CELL-MIGRATION; T-CELLS; APOPTOSIS; EXPRESSION; CARCINOMA;
D O I
10.3390/cancers12061421
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ovarian cancer is known for its aggressive pathological features, including the capacity to undergo epithelial to mesenchymal transition, promoting angiogenesis, metastatic potential, chemoresistance, inhibiting apoptosis, immunosuppression and promoting stem-like features. Galectins, a family of glycan-binding proteins defined by a conserved carbohydrate recognition domain, can modulate many of these processes, enabling them to contribute to the pathology of ovarian cancer. Our goal herein was to review specific galectin members identified in the context of ovarian cancer, with emphasis on their association with clinical and pathological features, implied functions, diagnostic or prognostic potential and strategies being developed to disrupt their negative actions.
引用
收藏
页数:28
相关论文
共 50 条
  • [1] Expression of Galectins in high grade serous ovarian cancer
    Labrie, Marilyne
    Communal, Laudine
    Vladoiu, Maria-Claudia
    Dupont, Pascal
    Mes-Masson, Anne-Marie
    St-Pierre, Yves
    CANCER RESEARCH, 2016, 76
  • [2] Galectins and cancer
    Danguy, A
    Camby, I
    Kiss, R
    BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1572 (2-3): : 285 - 293
  • [3] Galectins and urological cancer
    Oka, N
    Takenaka, Y
    Raz, A
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 91 (01) : 118 - 124
  • [4] Overall Survival of Ovarian Cancer Patients Is Determined by Expression of Galectins-8 and-9
    Schulz, Heiko
    Kuhn, Christina
    Hofmann, Simone
    Mayr, Doris
    Mahner, Sven
    Jeschke, Udo
    Schmoeckel, Elisa
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (01)
  • [5] Galectins-1,-3, and-7 Are Prognostic Markers for Survival of Ovarian Cancer Patients
    Schulz, Heiko
    Schmoeckel, Elisa
    Kuhn, Christina
    Hofmann, Simone
    Mayr, Doris
    Mahner, Sven
    Jeschke, Udo
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
  • [6] The role of galectins in colorectal cancer progression
    Barrow, Hannah
    Rhodes, Jonathan M.
    Yu, Lu-Gang
    INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (01) : 1 - 8
  • [7] Expression of galectins in cancer:: A critical review
    van den Brûle, F
    Califice, S
    Castronovo, V
    GLYCOCONJUGATE JOURNAL, 2002, 19 (7-9) : 537 - 542
  • [8] Role of galectins in lung cancer (Review)
    Chang, Wei-An
    Tsai, Ming-Ju
    Kuo, Po-Lin
    Hung, Jen-Yu
    ONCOLOGY LETTERS, 2017, 14 (05) : 5077 - 5084
  • [9] Galectins - Are dysregulated in human pancreatic cancer
    Berberat, PO
    Friess, H
    Wang, L
    Zhu, ZW
    Bley, T
    Frigeri, L
    Zimmermann, A
    Buechler, MW
    GASTROENTEROLOGY, 2001, 120 (05) : A164 - A164
  • [10] Galectins - Potential targets for cancer therapy
    Hasan, Syed Saif
    Ashraf, Ghulam Md.
    Banu, Naheed
    CANCER LETTERS, 2007, 253 (01) : 25 - 33