Matrix Metalloproteinases and Descending Aortic Aneurysms: Parity, Disparity, and Switch

Central to the pathologic changes in developing aortic aneurysms are alterations in the abundance and activity of proteases, of which the most important for aneurysm production comprise the matrix metalloproteinase (MMP) family. In this review, literature demonstrating the role of MMPs in the development of aortic aneurysms is presented, with emphasis on the parity and disparity between the thoracic and abdominal aorta. Furthermore, the role of embryologic cellular origins and evidence of phenotypic switch will be addressed in terms of how this process alters MMP production during aneurysm development. doi: 10.1111/j.1540-8191.2011.01315.x (J Card Surg 2012;27:81-90)