Dnmt3a silences hematopoietic stem cell self-renewal

被引：27
|
作者：
Trowbridge, Jennifer J. [1 ]
Orkin, Stuart H.
机构：
[1] Childrens Hosp Boston, Dept Pediat Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
NATURE GENETICS | 2012年 / 44卷 / 01期
关键词：
NOVO DNA METHYLTRANSFERASE; MUTATIONS;
D O I：
10.1038/ng.1043
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
引用
收藏
页码：13 / 14
页数：3
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