Dnmt3a silences hematopoietic stem cell self-renewal

被引：27
|
作者：
Trowbridge, Jennifer J. [1 ]
Orkin, Stuart H.
机构：
[1] Childrens Hosp Boston, Dept Pediat Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
NATURE GENETICS | 2012年 / 44卷 / 01期
关键词：
NOVO DNA METHYLTRANSFERASE; MUTATIONS;
D O I：
10.1038/ng.1043
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
引用
收藏
页码：13 / 14
页数：3
相关论文
共 50 条
  • [1] Dnmt3a silences hematopoietic stem cell self-renewal
    Jennifer J Trowbridge
    Stuart H Orkin
    Nature Genetics, 2012, 44 : 13 - 14
  • [2] miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a
    Hu, Wenhuo
    Dooley, James
    Chung, Stephen S.
    Chandramohan, Dhruva
    Cimmino, Luisa
    Mukherjee, Siddhartha
    Mason, Christopher E.
    de Strooper, Bart
    Liston, Adrian
    Park, Christopher Y.
    BLOOD, 2015, 125 (14) : 2206 - 2216
  • [3] Dnmt3b Is Dispensable for Hematopoietic Stem Cell Differentiation, but Acts Synergistically with Dnmt3a to Control the Balance Between Self-Renewal and Differentiation
    Mayle, Allison
    Challen, Grant Anthony
    Sun, Deqiang
    Jeong, Mira
    Luo, Min
    Chen, Rui
    Wang, Hui
    Li, Wei
    Goodell, Margaret A.
    BLOOD, 2012, 120 (21)
  • [4] Hematopoietic stem cell self-renewal
    Akala, Omobolaji O.
    Clarke, Michael F.
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (05) : 496 - 501
  • [5] CITED2 Cooperates with Low PU.1 and DNMT3A to Maintain Self-Renewal in Hematopoietic Stem Cells
    Schepers, Hein
    Korthuis, Patrick
    Geugien, Marjan
    Jaques, Jennifer
    Todorova, Tihomira I.
    Steidl, Ulrich
    Schuringa, Jan Jacob
    Vellenga, Edo
    BLOOD, 2015, 126 (23)
  • [6] Hematopoietic stem cell aging and self-renewal
    Dykstra, Brad
    de Haan, Gerald
    CELL AND TISSUE RESEARCH, 2008, 331 (01) : 91 - 101
  • [7] Hematopoietic stem cell aging and self-renewal
    Brad Dykstra
    Gerald de Haan
    Cell and Tissue Research, 2008, 331 : 91 - 101
  • [8] Regulation of hematopoietic stem cell self-renewal
    Reya, T
    RECENT PROGRESS IN HORMONE RESEARCH, VOL 58: HUMAN GENOME AND ENDOCRINOLOGY, 2003, 58 : 283 - 295
  • [9] The ERGonomics of hematopoietic stem cell self-renewal
    Lacadie, Scott A.
    Zon, Leonard I.
    GENES & DEVELOPMENT, 2011, 25 (04) : 289 - 293
  • [10] Dnmt3a is essential for hematopoietic stem cell differentiation
    Challen, Grant A.
    Sun, Deqiang
    Jeong, Mira
    Luo, Min
    Jelinek, Jaroslav
    Berg, Jonathan S.
    Bock, Christoph
    Vasanthakumar, Aparna
    Gu, Hongcang
    Xi, Yuanxin
    Liang, Shoudan
    Lu, Yue
    Darlington, Gretchen J.
    Meissner, Alexander
    Issa, Jean-Pierre J.
    Godley, Lucy A.
    Li, Wei
    Goodell, Margaret A.
    NATURE GENETICS, 2012, 44 (01) : 23 - U43
12345