Regulation by calcium of the synthesis of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in Walker 256 carcinosarcoma cells:: comparison with synthesis regulation from renal phenotype cells (LLC-PK1)

被引：1
|
作者：
del Campo, MJM [1 ]
Villameytide, MLT [1 ]
机构：
[1] Fdn Jimenez Diaz, Lab Bioquim, Secc Metab Mineral & Oseo, E-28040 Madrid, Spain
来源：
CANCER LETTERS | 1998年 / 134卷 / 02期
关键词：
Walker 256 carcinosarcoma cells; LLC-PK1; cells; 1,25-dihydroxyvitamin D-3; 24,25-dihydroxyvitamin D-3; calcium;
D O I：
10.1016/S0304-3835(98)00245-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this work was to study the regulation by calcium of the synthesis of 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) and 24,25-dihydroxyvitamin D-3 (24,25(OH)(2)D-3) in Walker 256 carcinosarcoma (W-256) cells compared to renal phenotype LLC-PK1 cells. We have detected synthesis of 1,25(OH)(2)D-3 and 24,25(OH)(2)D-3 in W-256 cells. Levels of 1,25(OH)(2)D-3 in W-256 were similar to those of LLC-PK1 cells. Levels of 24,25(OH)(2)D-3 were higher in W-256 than in LLC-PK1 cells. High levels of calcium inhibited 1,25(OH)(2)D-3 synthesis in LLC-PK1 cells but not in W-256 cells. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：147 / 153
页数：7
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