Copper-catalyzed α-amination of aliphatic aldehydes

被引：38
|
作者：
Tian, Jie-Sheng [1 ]
Loh, Teck-Peng [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637616, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 19期
关键词：
AMINO-ACIDS; ASYMMETRIC-SYNTHESIS; BOND-FORMATION; ENAMINES; FUNCTIONALIZATION; ALKYLATION; ACTIVATION; GENERATION;
D O I：
10.1039/c1cc11102g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient copper-catalyzed alpha-amination of aliphatic aldehydes for the synthesis of alpha-amino acetals using secondary amines with readily removable protecting groups as a nitrogen source was developed. This reaction can be operated under very mild conditions, affording the desired products in moderate to good yields.
引用
收藏
页码：5458 / 5460
页数：3
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