The challenge of hepatitis C in the HIV-infected person

被引：67
|
作者：
Thomas, David L. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD 21205 USA
来源：
ANNUAL REVIEW OF MEDICINE | 2008年 / 59卷
关键词：
HCV; coinfection; liver disease; injection drug use;
D O I：
10.1146/annurev.med.59.081906.081110
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatitis C virus (HCV) coinfection occurs in an estimated one quarter of HTV-infected persons in Europe, Australia, and the United States. As use of highly active antiretroviral drugs has markedly reduced opportunistic infections, HCV-related liver disease has emerged as a leading cause of death. HIV infection adversely affects both the natural history and the treatment of hepatitis C. Because there are no experimental models of coinfection and because the pathogenesis of each infection is incompletely understood, how HIV infection alters hepatitis C is not clear. This review considers the epidemiology, natural history, treatment, and pathogenesis of hepatitis C in HIV-infected persons.
引用
收藏
页码：473 / 485
页数：13
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