Cinchona-alkaloid-catalyzed enantioselective hydroxymethylation of 3-fluorooxindoles with paraformaldehyde

被引：6
|
作者：
Zhao, Jian-bo [1 ]
Ren, Xinfeng [1 ]
Zheng, Bu-quan [1 ]
Ji, Jian [1 ]
Qiu, Zi-bin [1 ]
Li, Ya [1 ]
机构：
[1] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, 333 Longteng Rd, Shanghai 201620, Peoples R China
来源：
JOURNAL OF FLUORINE CHEMISTRY | 2018年 / 215卷
基金：
上海市自然科学基金; 中国国家自然科学基金;
关键词：
Fluorine; Fluoroalkylation; Enantioselective; Condensation; Hydroxymethylation; N-FLUOROAMMONIUM SALTS; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ADDITION-REACTIONS; OXINDOLES; FLUORINATION; DESIGN; ACCESS; TRIFLUOROMETHYLATION; GENERATION;
D O I：
10.1016/j.jfluchem.2018.09.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Cinchona-alkaloid-catalyzed hydroxymethylation of 3-fluorooxindoles using paraformaldehyde as the Cl unit was achieved. A wide range of 3-fluorooxindoles was successfully reacted to give the corresponding 3-fluoro-3-hydroxymethyloxindoles with high efficiency and moderate to good enantioselectivity.
引用
收藏
页码：44 / 51
页数：8
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