Synthesis of 7-Aza-5-deazapurine Analogues via Copper(I)-Catalyzed Hydroamination of Alkynes and 1-Iodoalkynes

被引：23
|
作者：
Krasnova, Larissa B. [1 ]
Hein, Jason E. [1 ]
Fokin, Valery V. [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 24期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
5-AZA-7-DEAZAPURINE NUCLEOSIDES; BASE-PAIR; CYCLOADDITION; GUANINE; AZIDES; DNA;
D O I：
10.1021/jo1016376
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new method for the synthesis of dihydroimidazo[1,2-a]-[1,3,5]triazin-4(611)-ones via copper(I)-catalyzed hydro-amination was developed. In addition, for the first time, iodoalkynes were shown to participate in the copper(I)catalyzed intramolecular hydroamination reaction with exclusive formation of E-isomers.
引用
收藏
页码：8662 / 8665
页数：4
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