Autoimmune rheumatic diseases and their association with killer immunoglobulin-like receptor genes

被引：4

作者：

Salim, Patricia Hartstein

Jobim, Mariana ^{[2
]}

Jobim, Luiz Fernando ^{[2
]}

Xavier, Ricardo Machado ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Sch Med, Serv Rheumatol, HCPA, BR-90046900 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Sch Med, Serv Immunol, HCPA, BR-90046900 Porto Alegre, RS, Brazil

来源：

REVISTA BRASILEIRA DE REUMATOLOGIA | 2011年 / 51卷 / 04期

关键词：

autoimmunity; KIR receptors; systemic sclerosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HLA-C ALLELES; ANKYLOSING-SPONDYLITIS; KIR GENE; NK CELLS; CLASS-I; SUSCEPTIBILITY; POLYMORPHISMS; ORGANIZATION; CYTOTOXICITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Killer Immunoglobulin-like Receptor (KIR) genes express as receptors that activate or inhibit Natural Killer (NK) cells. The NK cells are part of the innate immune response and, through their KIR receptors, they identify target cells that have modified or different HLA (Human Leukocyte Antigen) molecules, inducing their lysis. The KIR receptors result from the expression of KIR genes (19q13.14) on the cell membrane of NK cells, which are polymorphic, and form haplotypes. The diversity of the frequency of KIR haplotypes in certain populations suggests that some individuals have different levels of protection against some diseases. The balance between cell inhibition and activation enables the NK cell to help the organism in immunological surveillance. In addition, there is evidence of the association of activating KIR genotypes with an increased risk for autoimmune disease.

引用

页码：351 / 364

页数：14

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