Stereoselective Nickel- Catalyzed [2+2] Cycloadditions of EneAllenes

被引：40
|
作者：
Noucti, Niamkou N. [1 ]
Alexanian, Erik J. [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 18期
基金：
美国国家科学基金会;
关键词：
alkenes; allenes; carbocycles; cycloaddition; nickel; ENE-ALLENES; TRANSITION; TRANSFORMATIONS; DERIVATIVES; MECHANISM;
D O I：
10.1002/anie.201411737
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A stereoselective nickel-catalyzed [2+ 2] cycloaddition of ene-allenes is reported. This transformation encompasses a broad range of ene-allene substrates, thus providing efficient access to fused cyclobutanes from easily accessed pcomponents. A simple and inexpensive first-row catalytic system comprised of [Ni(cod)(2)] and dppf was used in this process, thus constituting an attractive approach to synthetically challenging cyclobutane frameworks under mild reaction conditions.
引用
收藏
页码：5447 / 5450
页数：4
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