The design and evaluation of heparin-binding foldamers

被引：67
|
作者：
Choi, S
Clements, DJ
Pophristic, V
Ivanov, I
Vemparala, S
Bennett, JS
Klein, ML
Winkler, JD
DeGrado, WE [1 ]
机构：
[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA
[3] Univ Sci Philadelphia, Dept Chem & Biochem, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Med, Div Hematol & Oncol, Philadelphia, PA 19104 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 41期
关键词：
antithrombin; heparin; inhibitors; oligomers; protein interactions;
D O I：
10.1002/anie.200501279
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Controlling blood loss: The synthesis of a series of arylamide oligomers 1, which interact with heparin is described. The heparin-small molecule interaction inhibits the heparin's ability to activate antithrombin. These arylamide oligomers are the first example of low-molecular-weight antagonists that inhibit the anticoagulant function of heparin. (Chemical Equation Presented). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6685 / 6689
页数：5
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