How does vagal nerve stimulation (VNS) change EEG brain functional connectivity?

被引：46
|
作者：
Bartolomei, Fabrice [1 ,2 ]
Bonini, Francesca [1 ,2 ]
Vidal, Elsa [1 ]
Trebuchon, Agnes [1 ,2 ]
Lagarde, Stanislas [1 ,2 ]
Lambert, Isabelle [1 ]
McGonigal, Aileen [1 ,2 ]
Scavarda, Didier [4 ]
Carron, Romain [3 ]
Benar, Christian G. [1 ]
机构：
[1] Aix Marseille Univ, Inst Neurosci Syst, F-13005 Marseille, France
[2] Hop La Timone, AP HM, Serv Neurophysiol Clin, F-13005 Marseille, France
[3] Hop La Timone, AP HM, Serv Neurochirurg Fonct, F-13005 Marseille, France
[4] Hop La Timone, AP HM, Serv Neurochirurg Pediat, F-13005 Marseille, France
来源：
EPILEPSY RESEARCH | 2016年 / 126卷
关键词：
Vagus nerve; Stimulation; Functional connectivity; Focal epilepsy; EEG; Synchrony; TEMPORAL-LOBE EPILEPSY;
D O I：
10.1016/j.eplepsyres.2016.06.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An effect of vagal nerve stimulation (VNS) on cortical synchronization has been postulated but remains to be verified. In this study we investigated the impact of VNS on functional connectivity (Fc) using direct intracerebral recordings (stereotactic EEG, SEEG). Five patients with epilepsy who underwent SEEG recordings during ongoing VNS therapy were investigated. Interdependencies between twenty-six selected bipolar SEEG channels were estimated by nonlinear regression analysis during ON and OF periods of stimulation. In comparison with OFF periods, the ON periods disclosed higher values for four patients (P1, P3, P4, P5) and lower values for one patient (P2). From thresholded graphs, we observed increased connections between several brain regions in P1 and P5 and decreased connections in P2. Finally, the only decreased Fc occurring during VNS corresponded to the responder patient, suggesting that therapeutic impact might be related to this mechanism. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：141 / 146
页数：6
相关论文
共 50 条
  • [31] Early Use of Vagal Nerve Stimulation (VNS) in a Patient with New Onset Refractory Status Epilepticus (NORSE)
    Wong, Bonnie
    Yoo, Ji Yeoun
    Fields, Madeline
    [J]. NEUROLOGY, 2019, 92 (15)
  • [32] Stimulus frequency differences in respiratory inhibition is negligible to optimize vagal nerve stimulation (VNS) for heart failure
    [J]. 1600, Japan Soc. of Med. Electronics and Biol. Engineering (52)
  • [33] EEG synchronization of epileptiform activity in patients implanted with vagal nerve stimulator (VNS) results in favorable seizure control
    Koo, BK
    Ham, S
    Canady, A
    Beierwaltes, P
    [J]. NEUROLOGY, 2000, 54 (07) : A131 - A131
  • [34] Vagal Nerve Stimulation: The Effect on the Brain Oscillatory Field Potential
    Broncel, Adam
    Bocian, Renata
    Konopacki, Jan
    [J]. NEUROSCIENCE, 2022, 483 : 127 - 138
  • [35] EEG Reactivity Predicts Individual Efficacy of Vagal Nerve Stimulation in Intractable Epileptics
    Brazdil, Milan
    Dolezalova, Irena
    Koritakova, Eva
    Chladek, Jan
    Roman, Robert
    Pail, Martin
    Jurak, Pave
    Shaw, Daniel J.
    Chrastina, Jan
    [J]. FRONTIERS IN NEUROLOGY, 2019, 10
  • [36] Effect of vagal nerve stimulation on interictal epileptiform discharges:: A scalp EEG study
    Kuba, R
    Guzaninová, M
    Brázdil, M
    Novák, Z
    Chrastina, J
    Rektor, I
    [J]. EPILEPSIA, 2002, 43 (10) : 1181 - 1188
  • [37] Functional brain connectivity indexes derived from low-density EEG of pre-implanted patients as VNS outcome predictors
    Germany, Enrique
    Teixeira, Igor
    Danthine, Venethia
    Santalucia, Roberto
    Cakiroglu, Inci
    Torres, Andres
    Verleysen, Michele
    Delbeke, Jean
    Nonclercq, Antoine
    El Tahry, Riem
    [J]. JOURNAL OF NEURAL ENGINEERING, 2023, 20 (04)
  • [38] Does vagus nerve stimulation (VNS) effectively treat intractable epilepsy and does it meet patients' expectations?
    Barazi, SA
    Selway, RP
    Tawari, G
    Polkey, CE
    [J]. EPILEPSIA, 2005, 46 : 336 - 337
  • [39] REDUNDANCY IN FUNCTIONAL BRAIN CONNECTIVITY FROM EEG RECORDINGS
    Fallani, Fabrizio De Vico
    Toppi, Jlenia
    Di Lanzo, Claudia
    Vecchiato, Giovanni
    Astolfi, Laura
    Borghini, Gianluca
    Mattia, Donatella
    Cincotti, Febo
    Babiloni, Fabio
    [J]. INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 2012, 22 (07):
  • [40] Brain Functional Connectivity in Depression: Gender Differences in EEG
    Orgo, L.
    Bachmann, M.
    Kalev, K.
    Hinrikus, H.
    Jarvelaid, M.
    [J]. 2016 IEEE EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES), 2016, : 270 - 273
12345