How does vagal nerve stimulation (VNS) change EEG brain functional connectivity?

被引：46
|
作者：
Bartolomei, Fabrice [1 ,2 ]
Bonini, Francesca [1 ,2 ]
Vidal, Elsa [1 ]
Trebuchon, Agnes [1 ,2 ]
Lagarde, Stanislas [1 ,2 ]
Lambert, Isabelle [1 ]
McGonigal, Aileen [1 ,2 ]
Scavarda, Didier [4 ]
Carron, Romain [3 ]
Benar, Christian G. [1 ]
机构：
[1] Aix Marseille Univ, Inst Neurosci Syst, F-13005 Marseille, France
[2] Hop La Timone, AP HM, Serv Neurophysiol Clin, F-13005 Marseille, France
[3] Hop La Timone, AP HM, Serv Neurochirurg Fonct, F-13005 Marseille, France
[4] Hop La Timone, AP HM, Serv Neurochirurg Pediat, F-13005 Marseille, France
来源：
EPILEPSY RESEARCH | 2016年 / 126卷
关键词：
Vagus nerve; Stimulation; Functional connectivity; Focal epilepsy; EEG; Synchrony; TEMPORAL-LOBE EPILEPSY;
D O I：
10.1016/j.eplepsyres.2016.06.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
An effect of vagal nerve stimulation (VNS) on cortical synchronization has been postulated but remains to be verified. In this study we investigated the impact of VNS on functional connectivity (Fc) using direct intracerebral recordings (stereotactic EEG, SEEG). Five patients with epilepsy who underwent SEEG recordings during ongoing VNS therapy were investigated. Interdependencies between twenty-six selected bipolar SEEG channels were estimated by nonlinear regression analysis during ON and OF periods of stimulation. In comparison with OFF periods, the ON periods disclosed higher values for four patients (P1, P3, P4, P5) and lower values for one patient (P2). From thresholded graphs, we observed increased connections between several brain regions in P1 and P5 and decreased connections in P2. Finally, the only decreased Fc occurring during VNS corresponded to the responder patient, suggesting that therapeutic impact might be related to this mechanism. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：141 / 146
页数：6
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