Dual stimuli-responsive polymeric hollow nanocapsules as "smart" drug delivery system against cancer

被引：27
|
作者：
Jahanban-Esfahlan, Rana [1 ]
Massoumi, Bakhshali [2 ]
Abbasian, Mojtaba [2 ]
Farnudiyan-Habibi, Amir [3 ,4 ]
Samadian, Hadi [5 ]
Rezaei, Aram [5 ]
Derakhshankhah, Hossein [6 ]
Jaymand, Mehdi [5 ]
机构：
[1] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Biotechnol, Tabriz, Iran
[2] Payame Noor Univ, Dept Chem, Tehran, Iran
[3] Univ Tehran Med Sci, Dept Pharmaceut Biomat, Fac Pharm, Tehran, Iran
[4] Univ Tehran Med Sci, Med Biomat Res Ctr, Fac Pharm, Tehran, Iran
[5] Kermanshah Univ Med Sci, Hlth Technol Inst, Nano Drug Delivery Res Ctr, Kermanshah, Iran
[6] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran
来源：
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | 2020年 / 59卷 / 13期
关键词：
Nanomedicine; cancer chemotherapy; hollow nanocapsules; stimuli responsive; RADICAL POLYMERIZATION; NANOPARTICLES; COMBINATION; FORMULATION;
D O I：
10.1080/25740881.2020.1750652
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Novel thermal- and pH-responsive hollow nanocapsules (HNCaps) were fabricated through the grafting of a thiol-end capped PNIPAAm-b-PAA by thiol-ene "click" reaction onto PMMA HNCaps. The lowest critical solution temperature (LCST) of the fabricated HNCaps was obtained as 38-40 degrees C. The fabricated nanosystem was loaded with doxorubicin hydrochloride (Dox), and its drug loading and encapsulation efficiencies were obtained as 62 and 53%, respectively. The in vitro stimuli-responsive drug release behavior of the fabricated nanomedicine was investigated extensively. The anticancer activity of the drug-loaded HNCaps was evaluated using MTT assay against MCF7 cells. The results exhibited excellent potential of nanosystem as a drug delivery system (DDS) for cancer chemotherapy.
引用
收藏
页码：1492 / 1504
页数：13
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