Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

被引：227

作者：

Tomlinson, I

Bodmer, W

机构：

[1] Imperial Canc Res Fund, Mol & Populat Genet Lab, London WC2A 3PX, England

[2] John Radcliffe Hosp, Imperial Canc Res Fund, Inst Mol Med, Canc & Immunogenet Lab, Oxford OX3 9DZ, England

来源：

NATURE MEDICINE | 1999年 / 5卷 / 01期

关键词：

D O I：

10.1038/4687

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In considering tumorigenesis, much attention is paid to genome instability and mutation rates. While reflecting on the circumstances that have led to this emphasis on mutation rates, Ian Tomlinson and Walter Bodmer point out that an increased mutation rate does not necessarily cause a tumor to grow and that selection is in fact the mechanism that drives the cellular, somatic evolution that leads to cancer.

引用

页码：11 / 12

页数：2

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