Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents

被引：195
|
作者：
Karegoudar, Prakash [1 ,2 ]
Karthikeyan, Mari Sithambaram [1 ]
Prasad, Dasappa Jagadeesh [1 ]
Mahalinga, Manjathuru [1 ,2 ]
Holla, Bantwal Shivarama [1 ]
Kumari, Nalilu Sucheta [3 ]
机构：
[1] Mangalore Univ, Dept Chem, Mangalagangothri 574199, Karnataka, India
[2] Strides Res & Specialty Chem Ltd, Ind Area, New Mangalore, Karnataka, India
[3] KS Hegde Med Acad, Dept Biochem, Deralakatte 574162, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 02期
关键词：
2,3,5-trichlorobenzenecarbothioamide; 2,4-disubstitued thiazole; antibacterial; antifungal activity;
D O I：
10.1016/j.ejmech.2007.03.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel 4-aryl/chloroalkyl-2-(2,3,5-trichlorophenyl)-1,3-thiazoles (5a-g and 7a-e) were synthesized by condensing 2,3,5-trichlorobenzenecarbothioamide with phenacyl bromide/dichloroacetone. 2,3,5-Trichlorobenzaldehyde thiosemicarbazone on treatment with phenacyl bromide afforded 4-aryl-2-(2,3,5-trichlorophenylidenehydrazino)-1,3-thiazoles (10a-g) in good yield. The newly synthesized compounds are characterized by IR, H-1 NMR and mass spectral studies. These compounds were also screened for their antibacterial and antifungal activities. Preliminary results reveal that some of the synthesized compounds are showing promising antimicrobial activity. (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：261 / 267
页数：7
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