Toxic effects of several types of antifouling paints in human and rat hepatic or epidermal cells

被引:4
|
作者
de Sousa, G [1 ]
Delescluse, C
Pralavorio, M
Perichaud, M
Avon, M
Lafaurie, M
Rahmani, R
机构
[1] INRA, Ctr Rech, Lab Pharmacotoxicol Cellulaire & Mol, F-06606 Antibes, France
[2] Univ Aix Marseille 1, Lab Chim Macromol, F-13331 Marseille, France
[3] Technopole Chateau Gombert, HIGH TECH Environm, F-13454 Marseille, France
[4] Univ Nice, Lab Physiol & Toxicol Environm, Fac Med, F-06107 Nice, France
关键词
antifouling paints; CYP1A1; cytotoxicity; hepatocytes; HaCaT cells;
D O I
10.1016/S0378-4274(98)00048-4
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Fouling is the successive development of marine organisms on immersed surfaces, a process which has heavy negative economic impacts. Several antifouling technologies, generally based on the leaching of biocides from painted surfaces, have been developed, but these biocides are toxic to the environment. Hence, we compared the toxicity of several currently used paint lixiviats in rat hepatocytes, human HepG2 and HaCaT cells. Acute toxicity was assessed by the Neutral Red and MTT assays. Chronic effect was tested using induction of the 7-ethoxyresorufin-O-deethylase (EROD) activity as a marker. Large variations were observed among the various cell types or the antifouling formulations, both in terms of IC50 values (from similar to 0.5 to similar to 10%, v/v) and EROD induction (from similar to 1 to 10-fold over control). These differences appear to be related to variable biocide (copper compounds, organotins, etc...) concentrations in the different paint formulations, or to the specific metabolic capabilities of the cell system used. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:41 / 46
页数:6
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