Destruction of the tumor microenvironment by neoantigen-specific T cells prevents relapse of therapy -resistant cancer variants

被引:0
|
作者
Wolf, Steven [1 ]
Schreiber, Karin [1 ]
Steiner, Madeline [1 ]
Weichselbaum, Ralph [2 ]
Leisegang, Matthias [3 ]
Schreiber, Hans [1 ]
机构
[1] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Radiat Cellular Oncol, Chicago, IL 60637 USA
[3] Charite, Inst Immunol, Campus Buch, Berlin, Germany
关键词
D O I
10.1097/01.qai.0000557968.71935.dc
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
E-102
引用
收藏
页码:41 / 41
页数:1
相关论文
共 50 条
  • [31] Dynamics of neoantigen-specific T-cells in post-transplant relapse: do leukemia neoantigens elicit immune responses in transplant recipients?
    Neupane, Biswas
    Ventura, Kedwin
    Parr, Kayla
    Lee, Jui-En Ray
    Quann, Kevin
    Chen, Cai
    Barrett, A. John
    Ito, Sawa
    BONE MARROW TRANSPLANTATION, 2025, : 541 - 545
  • [32] Neoantigen-specific CD4+T cells induce protective, tumor-specific CD8+T cells in a mouse model of multiple myeloma.
    Bekri, Selma
    Rodney-Sandy, Reunet
    Bogen, Bjarne
    Levy, Daniel
    Cho, Hearn Jay
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E157 - E157
  • [33] Unsuccessful checkpoint blockade and vaccination therapy despite expansion of tumor neoantigen-specific CD8 T cells in the Lewis Lung Carcinoma (LLC) model
    Li, Shamin
    Simoni, Yannick
    Zhuang, Summer
    Ma, Shaokang
    Chee, Jonathan
    Redwood, Alec
    Robinson, Bruce
    Newell, Evan
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [34] Identification of neoantigen-specific T cell response and anti-tumour immunity in pancreatic cancer
    Du, X.
    Lin, W.
    Lyu, X.
    Huang, Y.
    He, K.
    Cao, J.
    Teng, L.
    ANNALS OF ONCOLOGY, 2020, 31 : S1363 - S1364
  • [35] Expanded ATLAS™-identified neoantigen-specific peripheral T cells (NPTs) demonstrate considerable neoantigen breadth, polyfunctionality, and effector function
    Perry, James R.
    Reuter, Mercay
    DeVault, Victoria L.
    Li, Adrienne
    Zope, Harshal
    DeOliveira, Daniel B.
    Khare, Pranay D.
    Jain, Manish
    Winstead, Colleen J.
    Lam, Hubert
    Flechtner, Jessica Baker
    JOURNAL OF IMMUNOLOGY, 2021, 206
  • [36] NEOANTIGEN-SPECIFIC TCR-T CELLS TARGETING SHARED HOTSPOT MUTATIONS FOR ADOPTIVE CELL THERAPY IN COMMON EPITHELIAL CANCERS
    Korngold, Ana
    Yong, Lin-Kin
    Ibekwe, Ugochi
    Simmons, Julissa
    Eckels, Phillip
    Figueroa, Elizabeth
    Hotard, Michelle
    Adeyemi, Frances
    Hunt, Thomas
    Markus, Tegan
    Hurton, Lenka
    Shi, Yaoyao
    Collinson-Pautz, Matthew
    Balasubramanian, Priya
    Wang, Cathy
    Andersson, Jourdan
    Heese, Lauren
    Khalil, Mariam
    Torres, David
    Olivares, Emarco
    Bardelli, Geraldine
    O'Brien, Kelly
    Hashmi, Haroon
    Chekmasova, Alena
    Baffa, Raffaele
    Spencer, Tom
    De Groot, Eleanor
    Deniger, Drew
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A240 - A240
  • [37] BNT221, AN AUTOLOGOUS NEOANTIGEN-SPECIFIC T-CELL PRODUCT FOR ADOPTIVE CELL THERAPY OF METASTATIC OVARIAN CANCER
    Arieta, Christina
    Velez, Diana
    Hannes, Susan
    Meda, Shirisha
    McCarthy, Brian
    Lenkala, Divya
    Harjanto, Dewi
    Suri, Prerna
    Kohler, Jessica
    Mcgee, Jonathan
    Kallin, Daniel
    Turcott, Paul
    Nijenhuis, Cynthia
    Rohaan, Maarje
    Sonke, Gabe
    Haanen, John
    DeMario, Mark
    Gaynor, Richard
    Van Buuren, Marit
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A212 - A212
  • [38] Tumor-specific T Cells Reprogram Mononuclear Phagocytes for Destruction of Checkpoint Blockade Resistant Pancreatic Cancer
    Roehle, K.
    Heid, D.
    Ventre, K.
    Ali, L. R.
    Lenehan, P.
    Heckler, M.
    Crowley, S. J.
    Stump, C.
    Godicelj, A.
    Yang, A.
    Biary, T.
    Bruck, P. T.
    Tegetoff, J.
    Nopper, S.
    Stanger, B. Z.
    Mancias, J.
    Agudo, J.
    Dougan, M.
    Dougan, K.
    PANCREAS, 2019, 48 (10) : 1511 - 1512
  • [39] Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach
    Johanns, Tanner M.
    Ward, Jeffrey P.
    Miller, Christopher A.
    Wilson, Courtney
    Kobayashi, Dale K.
    Bender, Diane
    Fu, Yujie
    Alexandrov, Anton
    Mardis, Elaine R.
    Artyomov, Maxim N.
    Schreiber, Robert D.
    Dunn, Gavin P.
    CANCER IMMUNOLOGY RESEARCH, 2016, 4 (12) : 1007 - 1015
  • [40] Identification of neoantigen-specific CD4+T cells with cytotoxic function in HLA class II positive endometrial cancer
    Tokita, Serina
    Fusagawa, Minami
    Murata, Kenji
    Kanaseki, Takayuki
    Torigoe, Toshihiko
    CANCER SCIENCE, 2025, 116 : 292 - 292