Advances in understanding the mechanism of zebrafish heart regeneration
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作者:
Kikuchi, Kazu
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机构:
Victor Chang Cardiac Res Inst, Dev & Stem Cell Biol Div, Darlinghurst, NSW 2010, Australia
Univ New S Wales, St Vincents Clin Sch, Kensington, NSW 2052, AustraliaVictor Chang Cardiac Res Inst, Dev & Stem Cell Biol Div, Darlinghurst, NSW 2010, Australia
Kikuchi, Kazu
[1
,2
]
机构:
[1] Victor Chang Cardiac Res Inst, Dev & Stem Cell Biol Div, Darlinghurst, NSW 2010, Australia
[2] Univ New S Wales, St Vincents Clin Sch, Kensington, NSW 2052, Australia
The adult mammalian heart was once believed to be a post-mitotic organ without any capacity for regeneration, but recent findings have challenged this dogma. A modified view assigns the mammalian heart a measurable capacity for regeneration throughout its lifetime, with the implication that endogenous regenerative capacity can be therapeutically stimulated in the injury setting. Although extremely limited in adult mammals, the natural capacity for organ regeneration is a conserved trait in certain vertebrates. Urodele amphibians and teleosts are well-known examples of such animals that can efficiently regenerate various organs including the heart as adults. By understanding how these animals regenerate a damaged heart, one might obtain valuable insights into how regeneration can be augmented in injured human hearts. Among the regenerative vertebrate models, the teleost zebrafish, Danio rerio, is arguably the best characterized with respect to cardiac regenerative responses. Knowledge is still limited, but a decade of research in this model has led to results that may help to understand how cardiac regeneration is naturally stimulated and maintained. This review surveys recent advances in the field and discusses current understanding of the endogenous mechanisms of cardiac regeneration in zebrafish. (C) 2014 The Author. Published by Elsevier B.V.
机构:
Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland
Stewart, Katherine M. Ross
Walker, Sophie L.
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Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland
Walker, Sophie L.
Baker, Andrew H.
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Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland
Baker, Andrew H.
Riley, Paul R.
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Univ Oxford, Dept Physiol Anat & Genet, Sherrington Bldg,Sherrington Rd, Oxford OX1 3PT, EnglandUniv Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland
Riley, Paul R.
Brittan, Mairi
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Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, ScotlandUniv Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland
机构:
Univ Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USA
Univ Minnesota, Stem Cell Inst, Minneapolis, MN USAUniv Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USA
Tahara, Naoyuki
Brush, Michael
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Univ Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USAUniv Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USA
Brush, Michael
Kawakami, Yasuhiko
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Univ Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USA
Univ Minnesota, Stem Cell Inst, Minneapolis, MN USAUniv Minnesota, Dept Genet Cell Biol & Dev, 321 Church St SE, Minneapolis, MN 55455 USA
机构:
Ctr Regenerat Med Barcelona, Barcelona, Spain
Networking Ctr Biomed Res Bioengn Biomat & Nanome, Barcelona, SpainSalk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
Sleep, Eduard
Boue, Stephanie
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Ctr Regenerat Med Barcelona, Barcelona, Spain
Networking Ctr Biomed Res Bioengn Biomat & Nanome, Barcelona, SpainSalk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
Boue, Stephanie
Jopling, Chris
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Ctr Regenerat Med Barcelona, Barcelona, SpainSalk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
Jopling, Chris
Raya, Marina
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Ctr Regenerat Med Barcelona, Barcelona, SpainSalk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
Raya, Marina
Raya, Angel
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机构:
Ctr Regenerat Med Barcelona, Barcelona, Spain
ICREA, Barcelona, Spain
Networking Ctr Biomed Res Bioengn Biomat & Nanome, Barcelona, SpainSalk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
Raya, Angel
Izpisua Belmonte, Juan Carlos
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机构:
Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
Ctr Regenerat Med Barcelona, Barcelona, SpainSalk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
机构:
Childrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Saban Res Inst, Program Dev Biol & Regenerat Med, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Surg, Div Cardiothorac Surg, Los Angeles, CA 90089 USA
Univ Calif San Diego, Dept Cardiol, San Diego, CA 92103 USAChildrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Rubin, Nicole
Harrison, Michael R.
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机构:
Childrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Saban Res Inst, Program Dev Biol & Regenerat Med, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Surg, Div Cardiothorac Surg, Los Angeles, CA 90089 USAChildrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Harrison, Michael R.
Krainock, Michael
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机构:
Childrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Saban Res Inst, Program Dev Biol & Regenerat Med, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Surg, Div Cardiothorac Surg, Los Angeles, CA 90089 USAChildrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Krainock, Michael
Kim, Richard
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机构:
Childrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Saban Res Inst, Program Dev Biol & Regenerat Med, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Surg, Div Cardiothorac Surg, Los Angeles, CA 90089 USAChildrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Kim, Richard
Lien, Ching-Ling
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机构:
Childrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA
Childrens Hosp Los Angeles, Saban Res Inst, Program Dev Biol & Regenerat Med, Los Angeles, CA 90027 USA
Univ Southern Calif, Keck Sch Med, Dept Surg, Div Cardiothorac Surg, Los Angeles, CA 90089 USA
Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USAChildrens Hosp Los Angeles, Saban Res Inst, Inst Heart, Los Angeles, CA 90027 USA