Self-Activation in De Novo Designed Mimics of Cell-Penetrating Peptides

被引：59
|
作者：
Som, Abhigyan [1 ]
Tezgel, A. Ozgul [1 ]
Gabriel, Gregory J. [1 ]
Tew, Gregory N. [1 ]
机构：
[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 27期
基金：
美国国家科学基金会;
关键词：
cell-penetrating peptides; peptidomimetics; polymers; vesicles; transduction; INTERNALIZATION MECHANISMS; BILAYER-MEMBRANES; RICH PEPTIDES; LIVE CELLS; OLIGOARGININE; TRANSLOCATION; PROTEINS; TAT; MACROPINOCYTOSIS; POLYARGININE;
D O I：
10.1002/anie.201101535
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
DIY transduction: Cell-penetrating peptides (CPPs) efficiently cross the nonpolar biological membrane, but activation by hydrophobic counterions is essential for transport activity. Polymeric mimics of CPPs are coupled with hydrophobic side chains; the "self-activation" in these species is demonstrated by transport of the fluorescent probe CF out of bilayer vesicles. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：6147 / 6150
页数：4
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