Self-Activation in De Novo Designed Mimics of Cell-Penetrating Peptides

被引：59

作者：

Som, Abhigyan ^{[1
]}

Tezgel, A. Ozgul ^{[1
]}

Gabriel, Gregory J. ^{[1
]}

Tew, Gregory N. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 27期

基金：

美国国家科学基金会;

关键词：

cell-penetrating peptides; peptidomimetics; polymers; vesicles; transduction; INTERNALIZATION MECHANISMS; BILAYER-MEMBRANES; RICH PEPTIDES; LIVE CELLS; OLIGOARGININE; TRANSLOCATION; PROTEINS; TAT; MACROPINOCYTOSIS; POLYARGININE;

D O I：

10.1002/anie.201101535

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DIY transduction: Cell-penetrating peptides (CPPs) efficiently cross the nonpolar biological membrane, but activation by hydrophobic counterions is essential for transport activity. Polymeric mimics of CPPs are coupled with hydrophobic side chains; the "self-activation" in these species is demonstrated by transport of the fluorescent probe CF out of bilayer vesicles. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6147 / 6150

页数：4

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