Hurdles on the road to personalized medicine

被引：11

作者：

Tursz, Thomas ^{[1
,2
]}

Bernards, Rene ^{[3
]}

机构：

[1] Inst Gustave Roussy, Dept Med, F-94800 Villejuif, France

[2] Univ Paris 11, Orsay, France

[3] Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands

来源：

MOLECULAR ONCOLOGY | 2015年 / 9卷 / 05期

基金：

欧洲研究理事会;

关键词：

Personalized medicine; Targeted therapy; Drug development; GENE-EXPRESSION PATTERNS; CLINICAL-APPLICATION; ACQUIRED-RESISTANCE; CANCER; SIGNATURE; SUBTYPES; THERAPY; HER2; EGFR;

D O I：

10.1016/j.molonc.2014.08.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer treatment is slowly shifting from an approach in which the tissue of origin and the histology were the guiding principles for the choice of chemotherapy towards a genotype-centric approach in which the changes in the cancer genome are used to select patients for treatment with highly selective and targeted drugs. This transition has all the hallmarks of a disruptive innovation and requires major adjustments in the way that cancer is diagnosed and treated. We discuss here the hurdles on the road ahead to a more personalized treatment of cancer. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：935 / 939

页数：5

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