The complement component C5 is not responsible for the alternative pathway activity in rabbit erythrocyte hemolytic assays during eculizumab treatment

被引:6
|
作者
van den Heuvel, Lambertus P. [1 ,2 ,3 ]
van de Kar, Nicole C. A. J. [1 ]
Duineveld, Caroline [4 ]
Sarlea, Andrei [1 ]
van der Velden, Thea J. A. M. [1 ]
Liebrand, Wilhelmus T. B. [1 ]
van Kraaij, Sanne [2 ]
Schjalm, Camilla [5 ,6 ]
Bouwmeester, Romy [1 ]
Wetzels, Jack F. M. [4 ]
Mollnes, Tom E. [5 ,6 ,7 ,8 ,9 ]
Volokhina, Elena B. [1 ,2 ]
机构
[1] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Pediat Nephrol, Amalia Childrens Hosp,Med Ctr, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Dept Lab Med, Nijmegen, Netherlands
[3] Univ Hosp Leuven, Dept Pediat, Leuven, Belgium
[4] Radboud Univ Nijmegen, Med Ctr, Radboud Inst Hlth Sci, Dept Nephrol, Nijmegen, Netherlands
[5] Oslo Univ Hosp, Dept Immunol, Oslo, Norway
[6] Univ Oslo, Oslo, Norway
[7] Nordland Hosp, Res Lab, Bodo, Norway
[8] Univ Tromso, KG Jebsen TREC, Tromso, Norway
[9] Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, Trondheim, Norway
关键词
THERAPY;
D O I
10.1038/s41423-020-0406-y
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:653 / 655
页数:3
相关论文
共 50 条
  • [31] Successful treatment of a PNH patient non-responsive to eculizumab with the novel complement C5 inhibitor coversin (nomacopan)
    Schols, Saskia
    Nunn, Miles A.
    Mackie, Ian
    Weston-Davies, Wynne
    Nishimura, Jun-ichi
    Kanakura, Yuzuru
    Blijlevens, Nicole
    Muus, Petra
    Langemeijer, Saskia
    BRITISH JOURNAL OF HAEMATOLOGY, 2020, 188 (02) : 334 - 337
  • [32] Properdin is essential for alternative pathway C5 convertase activity and C5b-9 formation
    Michels, Marloes
    Maas, Rianne
    van der Velden, Thea
    de Kar, Nicolevan
    Volokhina, Elena
    van den Heuvel, Bert
    MOLECULAR IMMUNOLOGY, 2022, 141 : 207 - 207
  • [33] HUMAN ALVEOLAR MACROPHAGES SYNTHESIZE THE FUNCTIONAL ALTERNATIVE PATHWAY OF COMPLEMENT AND ACTIVE C5 AND C9 INVITRO
    HETLAND, G
    JOHNSON, E
    AASEBO, U
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1986, 24 (05) : 603 - 608
  • [34] IMMUNOADSORBENT AFFINITY PURIFICATION OF THE 5TH COMPONENT (C5) OF HUMAN-COMPLEMENT AND DEVELOPMENT OF A HIGHLY SENSITIVE HEMOLYTIC ASSAY
    WETSEL, RA
    JONES, MA
    KOLB, WP
    JOURNAL OF IMMUNOLOGICAL METHODS, 1980, 35 (3-4) : 319 - 335
  • [35] Complement inhibition at the level of C3 or C5: mechanistic reasons for ongoing terminal pathway activity
    Mannes, Marco
    Dopler, Arthur
    Zolk, Oliver
    Lang, Sophia J.
    Halbgebauer, Rebecca
    Hoechsmann, Britta
    Skerra, Arne
    Braun, Christian K.
    Huber-Lang, Markus
    Schrezenmeier, Hubert
    Schmidt, Christoph Q.
    BLOOD, 2021, 137 (04) : 443 - 455
  • [36] Complement Inhibition at the Level of C3 or C5: Mechanistic Reasons for Ongoing Terminal Pathway Activity
    Mannes, M.
    Dopler, A.
    Zolk, O.
    TRANSPLANTATION, 2021, 105 (04) : 679 - 680
  • [37] Eculizumab, a C5 complement-blocking antibody, abolishes hemolysis and renders hemolytic patients with paroxysmal nocturnal hemoglobinuria (PNH) transfusion independent.
    Hillmen, R
    Hall, C
    Marsh, J
    Elebute, D
    Mojcik, CF
    Rollins, SA
    Richards, S
    Rother, RP
    BLOOD, 2002, 100 (11) : 44A - 44A
  • [38] COMPLEMENT COMPONENT C5 IS REQUIRED FOR RELEASE OF ALVEOLAR MACROPHAGE-DERIVED NEUTROPHIL CHEMOTACTIC ACTIVITY
    ROBBINS, RA
    RUSS, WD
    THOMAS, KR
    RASMUSSEN, JK
    KAY, HD
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1987, 135 (03): : 659 - 664
  • [39] C5 convertase of the alternative pathway of complement - Kinetic analysis of the free and surface-bound forms of the enzyme
    Rawal, N
    Pangburn, MK
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (27) : 16828 - 16835
  • [40] C5 convertase of the alternative pathway of complement: Enzymatic properties of the free and surface-bound forms of the enzyme
    Rawal, N
    Pangburn, MK
    MOLECULAR IMMUNOLOGY, 1998, 35 (6-7) : 392 - 392