Expanding the Known Functional Repertoire of the Human Cytomegalovirus pp71 Protein

被引：12
|
作者：
Kalejta, Robert F. [1 ]
Albright, Emily R. [1 ]
机构：
[1] Univ Wisconsin, McArdle Lab Canc Res, Inst Mol Virol, 1400 Univ Ave, Madison, WI 53706 USA
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2020年 / 10卷
基金：
美国国家卫生研究院;
关键词：
cytomegalovirus; HCMV; pp71; tegument; chromatin; latency; NUCLEAR DOMAIN 10; GENE-PRODUCT PP71; UBIQUITIN-INDEPENDENT DEGRADATION; INTRINSIC IMMUNE DEFENSE; CELL-CYCLE PROGRESSION; HIGHLY PATHOGENIC SIV; RETINOBLASTOMA PROTEIN; TEGUMENT PROTEINS; INTRACELLULAR-LOCALIZATION; PROTEASOMAL DEGRADATION;
D O I：
10.3389/fcimb.2020.00095
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The human cytomegalovirus pp71 protein is packaged within the tegument of infectious virions and performs multiple functions in host cells to prime them for productive, lytic replication. Here we review the known and hypothesized functions of pp71 in regulating proteolysis, infection outcome (lytic or latent), histone deposition, transcription, translation, immune evasion, cell cycle progression, and pathogenesis. We also highlight recent advances in CMV-based vaccine candidates informed by an improved understanding of pp71 function.
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页数：11
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