Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan

被引：11

作者：

Yen, Yung-Feng ^{[1
,2
]}

Pan, Sheng-Wei ^{[1
,3
]}

Su, Vincent Yi-Fong ^{[1
,2
]}

Chuang, Pei-Hung ^{[3
]}

Feng, Jia-Yih ^{[1
,3
]}

Su, Wei-Juin ^{[1
,3
]}

机构：

[1] Natl Yang Ming Univ, Taipei, Taiwan

[2] Taipei City Hosp, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Taipei, Taiwan

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 03期

关键词：

PULMONARY; NATIONWIDE; INFECTION; DIAGNOSIS; VACCINES; IMPACT;

D O I：

10.3201/eid2403.152071

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Experimental studies have demonstrated that influenza vaccination may protect against tuberculosis (TB) through a Th17 response. This nationwide cohort study aimed to evaluate the association of influenza vaccination with incident TB among elderly persons in Taiwan. This 2005-2012 study included 99,982 elderly persons (64,290 vaccinated and 35,692 unvaccinated) from the Taiwan National Health Insurance Research Database. During the 738,367 personyears of follow-up, 1,141 (1.14%) persons had incident TB. The cumulative incidences of TB were 145.2 cases/100,000 person-years among vaccinated elderly persons and 175.5 cases/100,000 person-years among unvaccinated elderly persons (p = 0.002). The time-dependent Cox proportional hazards model revealed that influenza vaccination was an independent protective factor for incident TB. Our results suggest that influenza vaccination is associated with a lower risk of incident TB among elderly persons in Taiwan. Further investigation of biologic mechanisms is warranted.

引用

页码：498 / 505

页数：8

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