Influenza Vaccination and Incident Tuberculosis among Elderly Persons, Taiwan

被引：11
|
作者：
Yen, Yung-Feng [1 ,2 ]
Pan, Sheng-Wei [1 ,3 ]
Su, Vincent Yi-Fong [1 ,2 ]
Chuang, Pei-Hung [3 ]
Feng, Jia-Yih [1 ,3 ]
Su, Wei-Juin [1 ,3 ]
机构：
[1] Natl Yang Ming Univ, Taipei, Taiwan
[2] Taipei City Hosp, Taipei, Taiwan
[3] Taipei Vet Gen Hosp, Taipei, Taiwan
来源：
EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 03期
关键词：
PULMONARY; NATIONWIDE; INFECTION; DIAGNOSIS; VACCINES; IMPACT;
D O I：
10.3201/eid2403.152071
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Experimental studies have demonstrated that influenza vaccination may protect against tuberculosis (TB) through a Th17 response. This nationwide cohort study aimed to evaluate the association of influenza vaccination with incident TB among elderly persons in Taiwan. This 2005-2012 study included 99,982 elderly persons (64,290 vaccinated and 35,692 unvaccinated) from the Taiwan National Health Insurance Research Database. During the 738,367 personyears of follow-up, 1,141 (1.14%) persons had incident TB. The cumulative incidences of TB were 145.2 cases/100,000 person-years among vaccinated elderly persons and 175.5 cases/100,000 person-years among unvaccinated elderly persons (p = 0.002). The time-dependent Cox proportional hazards model revealed that influenza vaccination was an independent protective factor for incident TB. Our results suggest that influenza vaccination is associated with a lower risk of incident TB among elderly persons in Taiwan. Further investigation of biologic mechanisms is warranted.
引用
收藏
页码：498 / 505
页数：8
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