Knowledge base and emerging trends in YAP1 research

Yes-associated protein 1 (YAP1) is a transcriptional coactivator that mediates the Hippo signaling pathway, which participates in the development and growth of the body; it plays key roles in tumorigenesis, metastasis, and therapy resistance. However, the pathophysiological mechanism of YAP1 has not been fully elucidated. Therefore, we explored the status and evolutionary trend in YAP1 research via bibliometric analysis. A total of 2,928 publications were downloaded from Web of Science Core Collection (WOSCC). The co-citation network map was drawn via CiteSpace and VOSviewer software. We analyzed the co-authorship networks among countries, journals, and authors, as well as co-occurrence of co-cited references, citation bursts, and keywords in YAP1 research, in order to predict its literature development. The present research evaluates the annual publication trends of YAP1 literature, and the following results were established: research on YAP1 are of steady increase; China present the highest co-citation; the Journal of Biological Chemistry (J Biol Chem) was the most productive journal, while Cell press received the most citations from co-cited references; Among the authors in the overall citations Bin Zhao is the most promising collaborator for emerging scholars in this field; and lastly, co-occurrence keyword analysis indicated that the emergingt rends in YAP1 research were mainly focused on cancer therapy. We established that projects on YAP1 research is presently in its rapid developmental stage with active global collaboration. In addition, the mechanism and clinical significance of YAP1 in cancer was established as the potential trend of future studies.