Bimodal targeting of inducible cytochromes P450 to mitochondria: Role in drug metabolism and toxicity

被引:0
|
作者
Avadhani, NG [1 ]
Anandatheerthavarada, HK [1 ]
Cook, M [1 ]
Chirumamilla, R [1 ]
机构
[1] Univ Penn, Sch Vet Med, Dept Biol Anim, Philadelphia, PA 19104 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:219 / 220
页数:2
相关论文
共 50 条
  • [31] Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam
    Yang, TJ
    Shou, M
    Korzekwa, KR
    Gonzalez, FJ
    Gelboin, HV
    Yang, SK
    BIOCHEMICAL PHARMACOLOGY, 1998, 55 (06) : 889 - 896
  • [32] Cytochromes P450 reconstituted with NADPH:: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes
    Kotrbova, Vera
    Aimova, Dagmar
    Brezinova, Anna
    Janouchova, Katerina
    Poljakova, Jitka
    Hodek, Petr
    Frei, Eva
    Stiborova, Marie
    NEUROENDOCRINOLOGY LETTERS, 2006, 27 : 18 - 22
  • [33] Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450
    Yang, Ruirui
    Luo, Zhiqiang
    Liu, Yang
    Sun, Mohan
    Zheng, Ling
    Chen, Yingying
    Li, Yanping
    Wang, Hao
    Chen, Lingzhu
    Wu, Ming
    Zhao, Huihui
    CURRENT DRUG METABOLISM, 2016, 17 (07) : 681 - 691
  • [34] Cytochromes p450 in medicinal chemistry and drug design
    de Groot, MJ
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2004, 4 (16) : 1731 - 1731
  • [35] Proposed new nomenclature for cattle cytochromes p450 involved in xenobiotic drug metabolism
    Zancanella, V.
    Giantin, M.
    Lopparelli, R. M.
    Dacasto, M.
    Negrisolo, E.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2009, 32 : 179 - 179
  • [36] In silico prediction and experimental validation of drug binding and metabolism:: The case of Cytochromes P450
    Vermeulen, NPE
    Keizers, P
    van Lipzig, MMH
    de Graaf, C
    Venhorst, J
    Feenstra, AE
    Commandeur, JNM
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 23 : S9 - S9
  • [37] Constitutive and inducible cytochromes P450 in rat lung mitochondria: Xenobiotic induction, relative abundance, and catalytic properties
    Bhagwat, SV
    Mullick, J
    Raza, H
    Avadhani, NG
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 1999, 156 (03) : 231 - 240
  • [38] Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver
    Lindros, KO
    GENERAL PHARMACOLOGY, 1997, 28 (02): : 191 - 196
  • [39] P450 oxidoredutase: genetic polymorphisms and implications for drug metabolism and toxicity
    Hart, Steven N.
    Zhong, Xiao-bo
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2008, 4 (04) : 439 - 452
  • [40] Basal and inducible expression of cytochromes P450 and related enzymes - Introduction
    Prough, RA
    FASEB JOURNAL, 1996, 10 (08): : 807 - 808